{
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  "Package": "simFastBOIN",
  "Type": "Package",
  "Title": "Fast Simulation of Bayesian Optimal Interval Designs for Phase I\nTrials",
  "Version": "2.1.0",
  "Date": "2026-10-13",
  "Authors@R": "person(given = \"Gosuke\",\nfamily = \"Homma\",\nrole = c(\"aut\", \"cre\"),\nemail = \"my.name.is.gosuke@gmail.com\",\ncomment = c(ORCID = \"0000-0002-6854-5627\"))",
  "Description": "Design and evaluate phase I dose-finding trials that use\nthe Bayesian optimal interval (BOIN) design of Liu and Yuan\n(2015) <doi:10.1111/rssc.12089>. Functions are provided to\ntabulate the decision boundaries, to simulate trials, to\nestimate the dose-toxicity curve under a monotonicity\nconstraint and to select the maximum tolerated dose. The\nsimulation engine is written in C++ and draws one random\nvariate per patient in enrollment order, which reproduces the\nreference implementation in the 'BOIN' package trial by trial\nfor a given seed. The traditional 3+3 design is provided as a\ncomparator, with operating characteristics obtained in closed\nform rather than by simulation. For toxicity that is observed\nlate, the time-to-event BOIN design is provided with the two\nestimators of Yuan and colleagues (2018)\n<doi:10.1158/1078-0432.CCR-18-0246> and Lin and Yuan (2020)\n<doi:10.1093/biostatistics/kxz007>. Patients who arrive while\nthe dose escalation waits can be backfilled to lower doses with\nthe designs of Zhao and colleagues (2024)\n<doi:10.1158/1078-0432.CCR-23-2585> and Chen and colleagues\n(2026) <doi:10.1007/s43441-026-00994-0>, the latter with the\nsuspension rules of Chen and colleagues (2025)\n<doi:10.1158/1078-0432.CCR-24-3669>. Trials of two drugs given\ntogether are handled by the drug-combination design of Lin and\nYin (2017) <doi:10.1177/0962280215594494>.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "Language": "en-US",
  "URL": "https://gosukehommaex.github.io/simFastBOIN/,\nhttps://github.com/gosukehommaEX/simFastBOIN",
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  "Author": "Gosuke Homma [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-6854-5627>)",
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    "be_boin_simulate",
    "bf_boin_simulate",
    "boin_boundary",
    "boin_decision_table",
    "boin_isotonic",
    "boin_lambda",
    "boin_p_tox",
    "boin_select_mtd",
    "boin_simulate",
    "boin_stopping_table",
    "comb_boin_next",
    "comb_boin_select_mtd",
    "comb_boin_simulate",
    "decision_table_3p3",
    "get_boin_boundary",
    "get_boin_decision",
    "get_boin_stopping_boundaries",
    "get_pts_and_tox",
    "isotonic_regression",
    "oc_3p3",
    "select_mtd",
    "sim_3p3",
    "sim_be_boin",
    "sim_be_boin_multi",
    "sim_bf_boin",
    "sim_bf_boin_multi",
    "sim_boin",
    "sim_boin_multi",
    "sim_comb_boin",
    "sim_comb_boin_multi",
    "sim_tite_boin",
    "sim_tite_boin_multi",
    "tite_boin_decision_table",
    "tite_boin_simulate"
  ],
  "_help": [
    {
      "page": "as.data.frame.boin_boundary",
      "title": "Coerce BOIN Decision Boundaries to a Data Frame",
      "topics": [
        "as.data.frame.boin_boundary"
      ]
    },
    {
      "page": "be_boin_simulate",
      "title": "Simulate BE-BOIN Trials",
      "topics": [
        "be_boin_simulate"
      ]
    },
    {
      "page": "bf_boin_simulate",
      "title": "Simulate BF-BOIN Trials",
      "topics": [
        "bf_boin_simulate"
      ]
    },
    {
      "page": "boin_boundary",
      "title": "Integer Decision Boundaries for the BOIN Design",
      "topics": [
        "boin_boundary"
      ]
    },
    {
      "page": "boin_decision_table",
      "title": "Decision Table for the BOIN Design",
      "topics": [
        "boin_decision_table"
      ]
    },
    {
      "page": "boin_isotonic",
      "title": "Isotonic Estimates of the DLT Probability",
      "topics": [
        "boin_isotonic"
      ]
    },
    {
      "page": "boin_lambda",
      "title": "Escalation and De-escalation Interval Boundaries",
      "topics": [
        "boin_lambda"
      ]
    },
    {
      "page": "boin_p_tox",
      "title": "Toxic Threshold Giving a Required De-escalation Boundary",
      "topics": [
        "boin_p_tox"
      ]
    },
    {
      "page": "boin_select_mtd",
      "title": "Select the MTD from Completed Trials",
      "topics": [
        "boin_select_mtd"
      ]
    },
    {
      "page": "boin_simulate",
      "title": "Simulate BOIN Trials",
      "topics": [
        "boin_simulate"
      ]
    },
    {
      "page": "boin_stopping_table",
      "title": "Safety Stopping Boundary as a Two-Row Table",
      "topics": [
        "boin_stopping_table"
      ]
    },
    {
      "page": "comb_boin_next",
      "title": "Next Dose Combination in a BOIN Drug-Combination Trial",
      "topics": [
        "comb_boin_next"
      ]
    },
    {
      "page": "comb_boin_select_mtd",
      "title": "Select the MTD Combination from Completed Drug-Combination Trials",
      "topics": [
        "comb_boin_select_mtd"
      ]
    },
    {
      "page": "comb_boin_simulate",
      "title": "Simulate BOIN Drug-Combination Trials",
      "topics": [
        "comb_boin_simulate"
      ]
    },
    {
      "page": "decision_table_3p3",
      "title": "Decision Table for the 3+3 Design",
      "topics": [
        "decision_table_3p3"
      ]
    },
    {
      "page": "oc_3p3",
      "title": "Exact Operating Characteristics of the 3+3 Design",
      "topics": [
        "oc_3p3"
      ]
    },
    {
      "page": "plot.boin_decision_table",
      "title": "Plot a BOIN Decision Table",
      "topics": [
        "plot.boin_decision_table"
      ]
    },
    {
      "page": "plot.comb_boin_next",
      "title": "Plot the Next Dose Combination of a BOIN Drug-Combination Trial",
      "topics": [
        "plot.comb_boin_next"
      ]
    },
    {
      "page": "plot.decision_table_3p3",
      "title": "Plot a 3+3 Decision Table",
      "topics": [
        "plot.decision_table_3p3"
      ]
    },
    {
      "page": "plot.tite_boin_decision_table",
      "title": "Plot a TITE-BOIN Decision Table",
      "topics": [
        "plot.tite_boin_decision_table"
      ]
    },
    {
      "page": "print.backfill_oc",
      "title": "Print Operating Characteristics of a BOIN Design with Backfilling",
      "topics": [
        "print.backfill_oc"
      ]
    },
    {
      "page": "print.backfill_oc_multi",
      "title": "Print Operating Characteristics of a Backfill Design Across Scenarios",
      "topics": [
        "print.backfill_oc_multi"
      ]
    },
    {
      "page": "print.backfill_trials",
      "title": "Print Simulated Trials of a BOIN Design with Backfilling",
      "topics": [
        "print.backfill_trials"
      ]
    },
    {
      "page": "print.boin_boundary",
      "title": "Print BOIN Decision Boundaries",
      "topics": [
        "print.boin_boundary"
      ]
    },
    {
      "page": "print.boin_decision_table",
      "title": "Print a BOIN Decision Table",
      "topics": [
        "print.boin_decision_table"
      ]
    },
    {
      "page": "print.boin_oc",
      "title": "Print Operating Characteristics of a BOIN Design",
      "topics": [
        "print.boin_oc"
      ]
    },
    {
      "page": "print.boin_oc_multi",
      "title": "Print Operating Characteristics Across Scenarios",
      "topics": [
        "print.boin_oc_multi"
      ]
    },
    {
      "page": "print.boin_trials",
      "title": "Print Simulated BOIN Trials",
      "topics": [
        "print.boin_trials"
      ]
    },
    {
      "page": "print.comb_boin_next",
      "title": "Print the Next Dose Combination of a BOIN Drug-Combination Trial",
      "topics": [
        "print.comb_boin_next"
      ]
    },
    {
      "page": "print.comb_boin_oc",
      "title": "Print Operating Characteristics of the BOIN Drug-Combination Design",
      "topics": [
        "print.comb_boin_oc"
      ]
    },
    {
      "page": "print.comb_boin_oc_multi",
      "title": "Print Operating Characteristics of the BOIN Drug-Combination Design Across Scenarios",
      "topics": [
        "print.comb_boin_oc_multi"
      ]
    },
    {
      "page": "print.comb_boin_trials",
      "title": "Print Simulated BOIN Drug-Combination Trials",
      "topics": [
        "print.comb_boin_trials"
      ]
    },
    {
      "page": "print.decision_table_3p3",
      "title": "Print a 3+3 Decision Table",
      "topics": [
        "print.decision_table_3p3"
      ]
    },
    {
      "page": "print.oc_3p3",
      "title": "Print Operating Characteristics of the 3+3 Design",
      "topics": [
        "print.oc_3p3"
      ]
    },
    {
      "page": "print.tite_boin_decision_table",
      "title": "Print a TITE-BOIN Decision Table",
      "topics": [
        "print.tite_boin_decision_table"
      ]
    },
    {
      "page": "print.tite_boin_oc",
      "title": "Print Operating Characteristics of a TITE-BOIN Design",
      "topics": [
        "print.tite_boin_oc"
      ]
    },
    {
      "page": "print.tite_boin_oc_multi",
      "title": "Print Operating Characteristics of a TITE-BOIN Design Across Scenarios",
      "topics": [
        "print.tite_boin_oc_multi"
      ]
    },
    {
      "page": "print.tite_boin_trials",
      "title": "Print Simulated TITE-BOIN Trials",
      "topics": [
        "print.tite_boin_trials"
      ]
    },
    {
      "page": "sim_3p3",
      "title": "Simulate the 3+3 Design",
      "topics": [
        "sim_3p3"
      ]
    },
    {
      "page": "sim_be_boin",
      "title": "Operating Characteristics of a BE-BOIN Design",
      "topics": [
        "sim_be_boin"
      ]
    },
    {
      "page": "sim_be_boin_multi",
      "title": "Operating Characteristics of a BE-BOIN Design Across Several Scenarios",
      "topics": [
        "sim_be_boin_multi"
      ]
    },
    {
      "page": "sim_bf_boin",
      "title": "Operating Characteristics of a BF-BOIN Design",
      "topics": [
        "sim_bf_boin"
      ]
    },
    {
      "page": "sim_bf_boin_multi",
      "title": "Operating Characteristics of a BF-BOIN Design Across Several Scenarios",
      "topics": [
        "sim_bf_boin_multi"
      ]
    },
    {
      "page": "sim_boin",
      "title": "Operating Characteristics of a BOIN Design",
      "topics": [
        "sim_boin"
      ]
    },
    {
      "page": "sim_boin_multi",
      "title": "Operating Characteristics Across Several Scenarios",
      "topics": [
        "sim_boin_multi"
      ]
    },
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      "title": "Operating Characteristics of the BOIN Drug-Combination Design",
      "topics": [
        "sim_comb_boin"
      ]
    },
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      "title": "Operating Characteristics of the BOIN Drug-Combination Design Across Scenarios",
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        "sim_tite_boin_multi"
      ]
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    {
      "page": "tite_boin_decision_table",
      "title": "Decision Table for the TITE-BOIN Design",
      "topics": [
        "tite_boin_decision_table"
      ]
    },
    {
      "page": "tite_boin_simulate",
      "title": "Simulate TITE-BOIN Trials",
      "topics": [
        "tite_boin_simulate"
      ]
    }
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      "engine": "knitr::rmarkdown",
      "headings": [
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