Package: simFastBOIN
Type: Package
Title: Fast Simulation of Bayesian Optimal Interval Designs for Phase I
        Trials
Version: 2.1.0
Date: 2026-10-13
Authors@R: person(given = "Gosuke",
                  family = "Homma",
                  role = c("aut", "cre"),
                  email = "my.name.is.gosuke@gmail.com",
                  comment = c(ORCID = "0000-0002-6854-5627"))
Description: Design and evaluate phase I dose-finding trials that use
        the Bayesian optimal interval (BOIN) design of Liu and Yuan
        (2015) <doi:10.1111/rssc.12089>. Functions are provided to
        tabulate the decision boundaries, to simulate trials, to
        estimate the dose-toxicity curve under a monotonicity
        constraint and to select the maximum tolerated dose. The
        simulation engine is written in C++ and draws one random
        variate per patient in enrollment order, which reproduces the
        reference implementation in the 'BOIN' package trial by trial
        for a given seed. The traditional 3+3 design is provided as a
        comparator, with operating characteristics obtained in closed
        form rather than by simulation. For toxicity that is observed
        late, the time-to-event BOIN design is provided with the two
        estimators of Yuan and colleagues (2018)
        <doi:10.1158/1078-0432.CCR-18-0246> and Lin and Yuan (2020)
        <doi:10.1093/biostatistics/kxz007>. Patients who arrive while
        the dose escalation waits can be backfilled to lower doses with
        the designs of Zhao and colleagues (2024)
        <doi:10.1158/1078-0432.CCR-23-2585> and Chen and colleagues
        (2026) <doi:10.1007/s43441-026-00994-0>, the latter with the
        suspension rules of Chen and colleagues (2025)
        <doi:10.1158/1078-0432.CCR-24-3669>. Trials of two drugs given
        together are handled by the drug-combination design of Lin and
        Yin (2017) <doi:10.1177/0962280215594494>.
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 3.5.0)
Imports: Iso, Rcpp (>= 1.0.0), stats, utils
LinkingTo: Rcpp
Suggests: BOIN, ggplot2 (>= 3.4.0), knitr, rmarkdown, spelling,
        testthat (>= 3.0.0)
Language: en-US
URL: https://gosukehommaex.github.io/simFastBOIN/,
        https://github.com/gosukehommaEX/simFastBOIN
BugReports: https://github.com/gosukehommaEX/simFastBOIN/issues
Config/testthat/edition: 3
VignetteBuilder: knitr
Config/roxygen2/version: 8.0.0
Repository: https://gosukehommaex.r-universe.dev
Date/Publication: 2026-10-16 09:43:08 UTC
RemoteUrl: https://github.com/gosukehommaex/simfastboin
RemoteRef: HEAD
RemoteSha: 7921ffaba7b50b2e0ec919f9831f7d46d52a88b6
NeedsCompilation: yes
Packaged: 2026-10-16 12:38:51 UTC; root
Author: Gosuke Homma [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-6854-5627>)
Maintainer: Gosuke Homma <my.name.is.gosuke@gmail.com>