Changes in version 1.0.0 (2025-11-21) Initial Release This is the first release of twoCoprimary, providing comprehensive tools for sample size and power calculation in clinical trials with two co-primary endpoints. Features - Two Continuous Endpoints - ss2Continuous(), power2Continuous(), twoCoprimary2Continuous() - Based on Sozu et al. (2011) - Supports known and unknown variance cases - Two Binary Endpoints (Asymptotic Methods) - ss2BinaryApprox(), power2BinaryApprox(), twoCoprimary2BinaryApprox() - Based on Sozu et al. (2010) - Four test methods: AN, ANc, AS, ASc - Two Binary Endpoints (Exact Methods) - ss2BinaryExact(), power2BinaryExact(), twoCoprimary2BinaryExact() - Based on Homma and Yoshida (2025) - Five exact tests: Chisq, Fisher, Fisher-midP, Z-pool, Boschloo - Mixed Continuous and Binary Endpoints - ss2MixedContinuousBinary(), power2MixedContinuousBinary(), twoCoprimary2MixedContinuousBinary() - Based on Sozu et al. (2012) - Supports biserial correlation structure - Mixed Count and Continuous Endpoints - ss2MixedCountContinuous(), power2MixedCountContinuous(), twoCoprimary2MixedCountContinuous() - Based on Homma and Yoshida (2024) - Handles overdispersed count data with negative binomial distribution Utility Functions - corrbound2Binary() - Calculate valid correlation bounds for binary endpoints - corrbound2MixedCountContinuous() - Calculate valid correlation bounds for count and continuous endpoints - design_table() - Create comprehensive design comparison tables - plot.twoCoprimary() - Visualize sample size vs correlation relationships Documentation - Six comprehensive vignettes covering all methodologies - Complete function documentation with examples - Validation against published results Testing - Comprehensive test suite with testthat - Tests for all major functions - Validation against published tables and results