Overview | Key Features | Installation | Basic Usage | Running a Basic BOIN Simulation | Understanding the Output | BOIN Standard Implementation | Key Parameters | Safety Features | Extra Safety Stopping | Maximum Conservatism | Multi-Scenario Simulations | Output Formatting Options | Percentage Format | Markdown Table Format | HTML Format | Accessing Detailed Results | Design Comparison | Performance Benchmarking | Advanced Features | Custom Cohort Sizes | Titration Phase | Stopping Reasons | References | See Also
Package: simFastBOIN 1.3.2
simFastBOIN: Fast Bayesian Optimal Interval Design for Phase I Dose-Finding Trials
Conducting Bayesian Optimal Interval (BOIN) design for phase I dose-finding trials. 'simFastBOIN' provides functions for pre-computing decision tables, conducting trial simulations, and evaluating operating characteristics. The package uses vectorized operations and the Iso::pava() function for isotonic regression to achieve efficient performance while maintaining full compatibility with BOIN methodology. Version 1.3.2 adds p_saf and p_tox parameters for customizable safety and toxicity thresholds. Version 1.3.1 fixes Date field. Version 1.2.1 adds comprehensive 'roxygen2' documentation and enhanced print formatting with flexible table output options. Version 1.2.0 integrated C-based PAVA for isotonic regression. Version 1.1.0 introduced conservative MTD selection (boundMTD) and flexible early stopping rules (n_earlystop_rule). Methods are described in Liu and Yuan (2015) <doi:10.1111/rssc.12089>.
Authors:
simFastBOIN_1.3.2.tar.gz
simFastBOIN_1.3.2.zip(r-4.7-any)simFastBOIN_1.3.2.zip(r-4.6-any)simFastBOIN_1.3.2.zip(r-4.5-any)
simFastBOIN_1.3.2.tgz(r-4.6-any)simFastBOIN_1.3.2.tgz(r-4.5-any)
simFastBOIN_1.3.2.tar.gz(r-4.7-any)simFastBOIN_1.3.2.tar.gz(r-4.6-any)
simFastBOIN_1.3.2.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
simFastBOIN/json (API)
| # Install 'simFastBOIN' in R: |
| install.packages('simFastBOIN', repos = c('https://gosukehommaex.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/gosukehommaex/simfastboin/issues
clinical-trialsdose-findingoncology-trialsphase1
Last updated from:b403d90c71. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 144 | ||
| source / vignettes | OK | 188 | ||
| linux-release-x86_64 | OK | 155 | ||
| macos-release-arm64 | OK | 135 | ||
| macos-oldrel-arm64 | OK | 111 | ||
| windows-devel | OK | 83 | ||
| windows-release | OK | 92 | ||
| windows-oldrel | OK | 102 | ||
| wasm-release | OK | 142 |
Exports:get_boin_boundaryget_boin_decisionget_boin_stopping_boundariesget_pts_and_toxisotonic_regressionselect_mtdsim_boinsim_boin_multi
Dependencies:base64encbslibcachemclicpp11digestevaluatefarverfastmapfontawesomefsgluehighrhtmltoolsIsojquerylibjsonlitekableExtraknitrlabelinglifecyclemagrittrmemoisemimeR6rappdirsRColorBrewerrlangrmarkdownrstudioapisassscalesstringistringrsvglitesystemfontstextshapingtinytexvctrsviridisLitexfunxml2yaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Calculate BOIN Escalation and De-escalation Boundaries | get_boin_boundary |
| Generate Dose Decision Table for BOIN Design | get_boin_decision |
| Generate Trial Stopping Rule Table | get_boin_stopping_boundaries |
| Generate Patient and Toxicity Data for BOIN Simulations | get_pts_and_tox |
| Isotonic Regression for Toxicity Rate Estimation | isotonic_regression |
| Print Method for BOIN Multi-Scenario Summary | print.boin_multi_summary |
| Print Method for BOIN Summary Objects | print.boin_summary |
| MTD Selection for Multiple Trials | select_mtd |
| Run BOIN Simulation with Operating Characteristics | sim_boin |
| Run BOIN Simulation for Multiple Scenarios | sim_boin_multi |
